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KMID : 0366220050400020124
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Korean Journal of Hematology
2005 Volume.40 No. 2 p.124 ~ p.128
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A Case of Reversal of Marrow Fibrosis following Imatinib Mesylate Therapy in a Patient with Chronic Myelogenous Leukemia Refractory to Interferon-α
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Kim Yeon-Sung
Kim Tae-Hun
Kim Won-Chul
Chun Yeon-Joo
Kil Uk-Hyun
Lee Hae-Kyung
Kim Yeong-Sik
Rho Sang-Young
Cho Seok-Goo
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Abstract
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Bone marrow fibrosis is associated with a poor prognosis in patients with chronic myelogenous leukemia (CML). It is present at initial diagnosis as well as in CML transformation. Although the effect of interferon-α therapy on marrow fibrosis has been controversial, imatinib mesylate has shown significant activity to reduce CML-associated bone marrow fibrosis as well as Philadelphia chromosome-positive cells. We report a case of reversal of marrow fibrosis after imatinib mesylate therapy in a 67 year-old female patient with CML refractory to interferon-α.
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KEYWORD
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Imatinib mesylate, Chronic myelogenous leukemia, Marrow fibrosis
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